PLCD4 antibody

Catalog No. ABIN7117488

This anti-PLCD4 antibody is a Rabbit Polyclonal antibody detecting PLCD4 in IHC and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for PLCD4 antibody (ABIN7117488)

Target: PLCD4 (Phospholipase C, delta 4 (PLCD4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLCD4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-PLCD4 Antibody

Purpose: PLCD4 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: phospholipase C, delta 4

Isotype: IgG

Application Details

Application Notes: IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PLCD4

Target: PLCD4 (Phospholipase C, delta 4 (PLCD4))

Alternative Name: PLCD4

Background:

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4)|Phosphoinositide phospholipase C-delta-4|Phospholipase C-delta-4 (PLC-delta-4)|PLCD4

Background: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate(PIP2) to generate 2 second messenger molecules diacylglycerol(DAG) and inositol 1,4,5-trisphosphate(IP3). DAG mediates the activation of protein kinase C(PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Gene ID: 84812

UniProt: Q9BRC7

Pathways: Inositol Metabolic Process